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Can people with no sexual experience have an STD?

Laura E asks:

If both the people involved in having sex have had no previous partners of any sexual nature, is it safe to presume they don't have any STDs?

Can you prevent STIs after the fact?

Jason asks:

Is there anything I can do to prevent STDs after having unprotected sex?

Safe, Sound & Sexy: A Safer Sex How-To

Because of the way that sexuality works in all of us, the more responsible we are, and the more safe and protected we feel, the easier it is to be really aroused and to enjoy sex: which is the point, right?